Society for Pediatric Pathology

Atlas Chapters

Gross appearance of Ganglioneuroma (Schwannian stroma-dominant): Tumor is solid and elastic with no hemorrhagic foci

Ganglioneuroma (Schwannian stroma-dominant), Maturing subtype. Maturing and mature ganglion cells as well as differentiating neuroblasts are found in a Schwannian stroma. In this stage of maturation, there are no pocket formations of neuroblastic/ganglion cells n a background of neuropil.

Ganglioneuroma (Schwannian stroma-dominant), maturing subtype. Along with completely mature ganglion cells, there are still neuroblastic cells on their way of maturation toward ganglion caells.

Ganglioneuroma (Schwannian stroma-dominant), Mature subtype. Note that completely mature ganglion cells are covered with satellite cells and individually embedded in a Schwannian stroma. Schwannian stroma is well-organized with fascicular formations.

Calcification in Ganglioneuroma, maturing subtype. Calcification can be seen in those tumors of Ganglineuroblastoma, intermixed and Ganglioneuroma.

Ganglioneuroma - Stroma Dominant

Tumors in this category are predominantly composed of ganglioneuromatous stroma with a minor component of scattered neuroblastic/ganglionic cells. There are no microscopically distinct neuroblastomatous foci. Schwannian stroma has a well-organized appearance of fascicular formation.
Tumor in the maturing subtype contains evenly or unevenly distributed differentiating neuroblasts and/or maturing ganglion cells, in addition to fully mature ganglion cells.
Tumor in the mature subtype contains fully mature ganglion cells which are usually surrounded by satellite cells.

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