Society for Pediatric Pathology

Atlas Chapters

Neuroblastoma showing in a fibrovascular septum a non-necrotizing sarcoid-type granuloma composed of epithelioid cells and multinucleated giant cells surrounded by a thin rim of lymphocytes.

Neuroblastoma showing marked desmoplastic reaction. Note the distorted nests of undifferentiated neuroblasts. This reaction may occur at the periphery of and also within the tumor. A biopsy from such an area can be challenging. Demonstration of appropriate clinical, immunohistochemical and molecular features will clinch the diagnosis.

Neuroblastoma showing prominent vesicular proliferation with formation of micronodular projections from the fibrovascular septum.

Neuroblastoma showing rhabdoid features characterized by presence of nucleolus and abundant cytoplasm with a suggestion of paranuclear hyaline inclusions. The nucleolus although present is not as prominent and large in most of the tumor cells as in a classic malignant rhabdoid tumor.

Neuroblastoma showing intra-nuclear cytoplasmic inclusions. Note that many of the tumor cells have discernible eosinophilic cytoplasm unlike most of the poorly differentiated and undifferentiated neuroblastoma.

Neuroblastoma showing a focus of alveolar pattern due to sloughing off of degenerative tumor cells in the central portions of what previously were lobules or nests.

Neuroblastoma showing a diffuse pattern. A few capillary-like vascular channels are present but nesting pattern with fibrovascular septa is absent

Rare Features - Other Patterns

Miscellaneous rare histologic features or patterns in neuroblastoma

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