Whether you are a Society for Pediatric Pathology (SPP) member or a visitor, we are glad you came to explore our site. This home page will let you know what is currently going on at the SPP, what has been added to the site, what new Meetings and Events have been listed, and what new Position ads have been recently posted. The Paediatric Pathology Society (PPS) comprises our European colleagues.

What's New
Latest SPP President's Message is now online. Please click here to read more.
Time to renew your SPP membership! If you haven't done so already, please click here to access.
Perspectives, Volume 28, Insights Into Pediatric Laboratory Medicine, and Volume 29, Soft Tissue Tumors in Children and Adolescents, can now be ordered online direct from Allen Press! Please click here to go to the Allen Press ordering page.

2015 Society for Pediatric Pathology Spring Meeting
March 21-22, 2015
Boston Marriott Copley Place
Boston, MA

Don't miss this opportunity to share your practice
experience and new discoveries with colleagues!

Preliminary Meeting Program

SPP Committee Meeting Schedule

Housing and Transportation Information


Thank you for submitting your abstracts!


Please use the Online Registration link below.

Online Registration

SPP Perinatal Pathology Course
Friday, April 17 - Sunday, April 19, 2015
Chicago, IL

Embassy Suites Downtown/Lakefront
511 N. Columbus Drive
Chicago, IL

Ona M. Faye-Petersen, M.D., Course Director
Linda Ernst, M.D., M.H.S., Assistant Course Director

Course Agenda

Course Objectives

Hotel Information


Please use the Online Registration link below.

Online Registration

Registration will include banquet, syllabi, and interaction with leading experts in the fields of perinatal medicine and perinatal pathology

2015 Society for Pediatric Pathology Fall Meeting
October 1-4, 2015
Eaton Chelsea Hotel
Toronto, ON

Skyline as viewed from Sam Smith

Please plan to join us in Toronto for the SPP Fall Meeting!

More information coming soon.

Prospective new members: Interested in joining the SPP? Please click here to create a userid and fill out a Membership Application online.

NOTE: Should you have any difficulties with the online registration, please
download the hardcopy membership application and either mail or FAX the completed application to the address/FAX# on the form.

For more information about membership options, please click here

Please note that membership dues are non-refundable

Please click the banner above to donate to the SPP now!

To learn more about our current fundraiser, please click here

Journal Watch
An eclectic selection of two dozen potentially interesting articles from current journals*

*Click here for the current watch list of journals.

All articles are in print. Please click the PMID number at the end of each citation to see the abstract on PubMed.

DISCLAIMER: Articles are listed in this section for information purposes only. The SPP does not approve or endorse these articles, and the SPP is not responsible for their content.

January 2015 Update
This month's Journal Watch prepared by Jefferson Terry, MD, PhD, FRCPC, McMaster University Medical Center, Hamilton, Ontario.

Click here to download the January 2015 Journal Watch list

  • Chitkara Y. Upfront Special Staining for Helicobacter pylori in Gastric Biopsy Specimens Is Not Indicated. Am J Clin Pathol. 2015 Jan;143(1):84-8. PMID: 25511146.
  • Tanner SM, Berryhill TF, Ellenburg JL, et al. Pathogenesis of Necrotizing Enterocolitis: Modeling the Innate Immune Response. Am J Pathol. 2015 Jan;185(1):4-16. PMID: 25447054.
  • Tsukahara T, Watanabe K, Watanabe T, et al. Tumor Necrosis Factor α Decreases Glucagon-Like Peptide-2 Expression by Up-Regulating G-Protein-Coupled Receptor 120 in Crohn Disease. Am J Pathol. 2015 Jan;185(1):185-96. PMID: 25447053.
  • Milner JD, Vogel TP, Forbes L, et al. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 2015 Jan 22;125(4):591-9. PMID: 25359994.
  • Perez-Andreu V, Roberts KG, Xu H, et al. A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. Blood. 2015 Jan 22;125(4):680-6. PMID: 25468567.
  • Gittleman HR, Ostrom QT, Rouse CD, et al. Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010. Cancer. 2015 Jan 1;121(1):102-12. PMID: 25155924.
  • Messinger YH, Stewart DR, Priest JR, et al. Pleuropulmonary blastoma: A report on 350 central pathology-confirmed pleuropulmonary blastoma cases by the International Pleuropulmonary Blastoma Registry. Cancer. 2015 Jan 15;121(2):276-85. PMID: 25209242.
  • Tamplin OJ, Durand EM, Carr LA, et al. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15;160(1-2):241-52. PMID: 25594182.
  • Worthley DL, Churchill M, Compton JT, et al. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell. 2015 Jan 15;160(1-2):269-84. PMID: 25594183.
  • Huch M, Gehart H, van Boxtel R, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 2015 Jan 15;160(1-2):299-312. PMID: 25533785.
  • Frazier AL, Hale JP, Rodriguez-Galindo C, et al. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United kingdom and United States. J Clin Oncol. 2015 Jan 10;33(2):195-201. PMID: 25452439.
  • Suarez F, Mahlaoui N, Canioni D, et al. Incidence, presentation, and prognosis of malignancies in ataxia-telangiectasia: a report from the French national registry of primary immune deficiencies. J Clin Oncol. 2015 Jan 10;33(2):202-8. PMID: 25488969.
  • Federico SM, Allewelt HB, Spunt SL, et al. Subsequent malignant neoplasms in pediatric patients initially diagnosed with neuroblastoma. J Pediatr Hematol Oncol. 2015 Jan;37(1):e6-e12. PMID: 24633303.
  • Downey LC, O'Shea TM, Allred EN, et al. Antenatal and early postnatal antecedents of parent-reported attention problems at 2 years of age. J Pediatr. 2015 Jan;166(1):20-25.e1. PMID: 25241173.
  • Heissat S, Collardeau-Frachon S, Baruteau J, et al. Neonatal Hemochromatosis: Diagnostic Work-Up Based on a Series of 56 Cases of Fetal Death and Neonatal Liver Failure. J Pediatr. 2015 Jan;166(1):66-73. PMID: 25444000.
  • Hopkins PV, Campbell C, Klug T, et al. Lysosomal storage disorder screening implementation: findings from the first six months of full population pilot testing in Missouri. J Pediatr. 2015 Jan;166(1):172-7. PMID: 25444528.
  • Acker SN, Mandell EW, Sims-Lucas S, et al. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr. 2015 Jan;166(1):178-83. PMID: 25306189.
  • Kopp LM, Hu C, Rozo B, White-Collins A, et al. Utility of bone marrow aspiration and biopsy in initial staging of Ewing sarcoma. Pediatr Blood Cancer. 2015 Jan;62(1):12-5. PMID: 25174337.
  • Chen CM, Chou HC, Huang LT. Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat offspring. Pediatr Res. 2015 Jan;77(1-1):56-63. PMID: 25279991.
  • Robinson DT, Caplan MS. Linking fat intake, the intestinal microbiome, and necrotizing enterocolitis in premature infants. Pediatr Res. 2015 Jan;77(1-2):121-126. PMID: 25303279.
  • Jacob J, Kamitsuka M, Clark RH, et al. Etiologies of NICU Deaths. Pediatrics. 2015 Jan;135(1):e59-65. PMID: 25489010.
  • Kaatsch P, Häfner C, Calaminus G, et al. Pediatric germ cell tumors from 1987 to 2011: incidence rates, time trends, and survival. Pediatrics. 2015 Jan;135(1):e136-43. PMID: 25489016.
  • Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015 Jan 2;347(6217):78-81. PMID: 25554788.
  • Uhlén M, Fagerberg L, Hallström BM, et al. Proteomics. Tissue-based map of the human proteome. Science. 2015 Jan 23;347(6220):1260419. PMID: 25613900.

Holiday 2014 Update
This Journal Watch prepared by Jason A. Jarzembowski, MD, PhD, Children's Hospital of Wisconsin, Milwaukee, WI.

Click here to download the 2014 Journal Watch Holiday Edition.

  • Aslan B, Stemp J, Yip P, Gun-Munro J. Method Precision and Frequent Causes of Errors Observed in Point-of-Care Glucose Testing: A Proficiency Testing Program Perspective. Am J Clin Pathol. 2014 Dec;142(6):857-63. PubMed PMID: 25389340.
  • Rao LK, Gilbertson JR. Longitudinal engagement of pathology residents: a proposed approach for informatics training. Am J Clin Pathol. 2014 Dec;142(6):748-54. PubMed PMID: 25389327.
  • Loh TP, Ranieri E, Metz MP. Derivation of pediatric within-individual biological variation by indirect sampling method: an LMS approach. Am J Clin Pathol. 2014 Nov;142(5):657-63. PubMed PMID: 25319981.
  • Camperlengo L, Shapiro-Mendoza CK, Gibbs F. Improving Sudden Unexplained Infant Death Investigation Practices: An Evaluation of the Centers for Disease Control and Prevention's SUID Investigation Training Academies. Am J Forensic Med Pathol. 2014 Dec;35(4):278-82. PubMed PMID: 25330248.
  • Bakirtzi K, West G, Fiocchi C, Law IK, et al. The Neurotensin-HIF-1α-VEGFα Axis Orchestrates Hypoxia, Colonic Inflammation, and Intestinal Angiogenesis. Am J Pathol. 2014 Dec;184(12):3405-14. PubMed PMID: 25307345.
  • Lubeck BA, Lapinski PE, Bauler TJ, Oliver JA, et al. Blood Vascular Abnormalities in Rasa1(R780Q) Knockin Mice: Implications for the Pathogenesis of Capillary Malformation-Arteriovenous Malformation. Am J Pathol. 2014 Dec;184(12):3163-9. PubMed PMID: 25283357.
  • Banet N, Gown AM, Shih IM, Kay Li Q, et al. GATA-3 Expression in Trophoblastic Tissues: An Immunohistochemical Study of 445 Cases, Including Diagnostic Utility. Am J Surg Pathol. 2014 Sep 3. [Epub ahead of print] PubMed PMID: 25188865.
  • Ma C, Giardiello FM, Montgomery EA. Upper tract juvenile polyps in juvenile polyposis patients: dysplasia and malignancy are associated with foveolar, intestinal, and pyloric differentiation. Am J Surg Pathol. 2014 Dec;38(12):1618-26. PubMed PMID: 25390638.
  • Méhes G, Irsai G, Bedekovics J, Beke L, et al. Activating BRAF V600E Mutation in Aggressive Pediatric Langerhans Cell Histiocytosis: Demonstration by Allele-specific PCR/Direct Sequencing and Immunohistochemistry. Am J Surg Pathol. 2014 Dec;38(12):1644-8. PubMed PMID: 25118810.
  • Linos K, Carter JM, Gardner JM, Folpe AL, et al. Myofibromas with atypical features: expanding the morphologic spectrum of a benign entity. Am J Surg Pathol. 2014 Dec;38(12):1649-54. PubMed PMID: 24921644.
  • Treetipsatit J, Hazard FK. Features of gastric and colonic mucosa in congenital enteropathies: a study in histology and immunohistochemistry. Am J Surg Pathol. 2014 Dec;38(12):1697-706. PubMed PMID: 25007148.
  • La Starza R, Borga C, Barba G, Pierini V, et al. Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations. Blood. 2014 Dec 4;124(24):3577-82. PubMed PMID: 25270907.
  • Grimwade D, Freeman SD. Defining minimal residual disease in acute myeloid leukemia: which platforms are ready for "prime time"? Blood. 2014 Nov 27;124(23):3345-3355. Epub 2014 Jul 21. Review. PubMed PMID: 25049280.
  • Irving J, Matheson E, Minto L, Blair H, et al. Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood. 2014 Nov 27;124(23):3420-30. PubMed PMID: 25253770, PubMed Central PMCID: PMC4246039.
  • Heitink-Pollé KM, Nijsten J, Boonacker CW, de Haas M, Bruin MC. Clinical and laboratory predictors of chronic immune thrombocytopenia in children: a systematic review and meta-analysis. Blood. 2014 Nov 20;124(22):3295-307. Epub 2014 Oct 10. PubMed PMID: 25305206.
  • Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE. Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma. Cancer. 2014 Dec 15;120(24):3987-93. PubMed PMID: 25116228.
  • Chipumuro E, Marco E, Christensen CL, Kwiatkowski N, et al. CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer. Cell. 2014 Nov 20;159(5):1126-39. PubMed PMID: 25416950, PubMed Central PMCID: PMC4243043.
  • Kao CS, Ulbright TM, Idrees MT. Gonadoblastoma: an immunohistochemical study and comparison to Sertoli cell nodule with intratubular germ cell neoplasia, with pathogenetic implications. Histopathology. 2014 Dec;65(6):861-7. PubMed PMID: 24766183.
  • Adamson SL. sFLT1 in preeclampsia: trophoblast defense against a decidual VEGFA barrage? J Clin Invest. 2014 Nov 3;124(11):4690-2. PubMed PMID: 25329689.
  • Marques Howarth M, Simpson D, Ngok SP, Nieves B, et al. Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. J Clin Invest. 2014 Dec 1;124(12):5275-90. PubMed PMID: 25401475.
  • Blatt J, Powell CM, Burkhart CN, Stavas J, Aylsworth AS. Genetics of hemangiomas, vascular malformations, and primary lymphedema. J Pediatr Hematol Oncol. 2014 Nov;36(8):587-93. PubMed PMID: 25222064.
  • Baroni LV, Sampor C, Fandiño A, Solernou V, et al. Anterior segment invasion in retinoblastoma: is it a risk factor for extraocular relapse? J Pediatr Hematol Oncol. 2014 Nov;36(8):e509-12. PubMed PMID: 24732059.
  • Hamm JA, Mikhail FM, Hollenbeck D, Farmer M, Robin NH. Incidental detection of cancer predisposition gene copy number variations by array comparative genomic hybridization. J Pediatr. 2014 Nov;165(5):1057-1059.e4. PubMed PMID: 25201531.
  • Dias C, Feng J, Sun H, Shao NY, et al. β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature. 2014 Dec 4;516(7529):51-5. PubMed PMID: 25383518, PubMed Central PMCID: PMC4257892.
  • Hashizume R, Andor N, Ihara Y, Lerner R, et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec;20(12):1394-6. PubMed PMID: 25401693, PubMed Central PMCID: PMC4257862.
  • Zhang J, Li C, Lv L, Yang C, et al. Clinical and experimental study of castleman disease in children. Pediatr Blood Cancer. 2015 Jan;62(1):109-14. PubMed PMID: 25213773.
  • Cohen-Gogo S, Cellier C, Coindre JM, Mosseri V, et al. Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Société Française des Cancers de L'Enfant. Pediatr Blood Cancer. 2014 Dec;61(12):2191-8. PubMed PMID: 25176412.
  • Di Rocco M, Andria G, Deodato F, Giona F, et al. Early diagnosis of Gaucher disease in pediatric patients: proposal for a diagnostic algorithm. Pediatr Blood Cancer. 2014 Nov;61(11):1905-9. PubMed PMID: 25131373.
  • Mussa A, Pagliardini S, Pagliardini V, Molinatto C, et al. α-Fetoprotein assay on dried blood spot for hepatoblastoma screening in children with overgrowth-cancer predisposition syndromes. Pediatr Res. 2014 Dec;76(6):544-8. PubMed PMID: 25167201.
  • Holm LL, Rose MV, Kimaro G, Bygbjerg IC, et al. A Comparison of Interferon-γ and IP-10 for the Diagnosis of Tuberculosis. Pediatrics. 2014 Dec;134(6):e1568-75. PubMed PMID: 25422019.

Click here for previous journal watch listings.

From the Editor's Desk

Dear Colleagues:

Late fall greetings! The SPP 2015 Spring Meeting will be held at the Boston Marriott Copley Place, Boston, MA, on March 21 and 22, 2015. Abstract submission is now open. You can submit your abstract by clicking here. Abstract submission will close on Thursday, November 20, 2014, at 11:59 P.M. Central Time. Housing and transportation information is available by clicking here.

By all accounts the Fall Joint Meeting of PPS and SPP, held September 4 through 6, 2014, at Birmingham UK was very successful. Congratulations to all of the SPP Award winners announced at the meeting. Award winners are listed in the most recent report from Fusun Gundogan of the Distinctions and Awards Committee, which can be viewed by clicking here. If I may, I would like to offer a special tip of the hat to Bahig Shehata for winning the Harry B. Neustein Memorial Award for an unprecedented third time (2008, 2010, and 2014).

Robert E Ruiz
SPP Website Editor

Questions and comments about website content can be directed to the website editor. Technical concerns can be directed to the site webmaster.